1-(2-甲基丙基)-4-氯-1H-咪唑并[4,5-c]喹啉合成路线 （共 18 条）
反应条件
1: 17.8 g / Et3N / CH2Cl2 / 0.5 h / Heating 2: H2; MgSO4 / Pt/C / ethyl acetate / 2585.74 Torr 3: 61 percent / toluene / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491
反应条件
in chloroform; orthoformic acid triethyl ester
反应条件
1: peracetic acid / ethanol / 2.5 h / 60 °C 2: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491
反应条件
1: 1 h / Heating 2: peracetic acid / ethanol / 2.5 h / 60 °C 3: 49 percent / POCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3481 - 3491
反应条件
ammonia in dimethyl sulfoxide T=20 - 150°C; P=1875.19 - 3750.38 Torr; 6 - 12 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: US2008/194822 A1, 2008 ;
Location in patent: Page/Page column 2-3 ;
参考文献
Riker Laboratories, Inc.
Patent: US4689338 A1, 1987 ;
US 4689338 A
反应条件
1: in dimethyl sulfoxide T=140 - 150°C; 1 h; 2: With sodium hydroxide; water in dimethyl sulfoxide T=20 - 60°C; pH=10 - 11; 2 h; Product distribution / selectivity;
参考文献
CHEMAGIS LTD.
Patent: US2008/177074 A1, 2008 ;
Location in patent: Page/Page column 5 ;
参考文献
Riker Laboratories, Inc.
Patent: US4689338 A1, 1987 ;
US 4689338 A
