反应条件
1: 100 percent / H2 / 5percent Pd/C / ethanol / 18 h / 760 Torr
2: 22 percent / trifluoroacetic acid
3: 86 percent / K2CO3 / methanol / 1.5 h / 55 °C
4: 84 percent / glac. AcOH, sodium cyanoborohydride / 3 h / Ambient temperature
View Scheme
参考文献
Bromidge, Steven M.; Dabbs, Steven; Davies, David T.; Duckworth, D. Malcolm; Forbes, Ian T.; Ham, Peter; Jones, Graham E.; King, Frank D.; Saunders, Damian V.; Starr, Susannah; Thewlis, Kevin M.; Wyman, Paul A.; Blaney, Frank E.; Naylor, Christopher B.; Bailey, Fiona; Blackburn, Thomas P.; Holland, Vicky; Kennett, Guy A.; Riley, Graham J.; Wood, Martyn D.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1598 - 1612