2-氨基-4-硝基甲苯合成路线 （共 108 条）
反应条件
in acetic acid
T=120 - 130°C; 0.5 h;
参考文献
Artico; Corelli; Massa; Stefancich; Panico; Simonetti
Farmaco, Edizione Scientifica, 1984 , vol. 39, # 11 p. 910 - 924
反应条件
1: 63 percent / acetic acid / 0.5 h / 120 - 130 °C
2: hydrogen / 10percent Pd/C / ethanol
View Scheme
参考文献
Artico; Corelli; Massa; Stefancich; Panico; Simonetti
Farmaco, Edizione Scientifica, 1984 , vol. 39, # 11 p. 910 - 924
反应条件
1: acetic acid / acetonitrile / 0.25 h
2: potassium permanganate / water / 1.5 h / 80 °C
View Scheme
参考文献
Heppell, Jacob; Al-Rawi, Jasim
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 162 - 174
反应条件
1: 73 percent / triethylamine / dioxane; benzene / 12 h / Heating
2: 71 percent / H2 / 10percent Pd/C / dimethylformamide / 25 °C / 2280 Torr
View Scheme
参考文献
Vittenet
Bulletin de la Societe Chimique de France, 1899 , vol. <3>21, p. 662
反应条件
1: ice; concentrated hydrochloric acid / mit NaNO2 diazotieren und in CuCl-Loesung giessen
2: permanganate
3: potassium carbonate; copper powder
View Scheme
参考文献
Ullmann; Wagner
Justus Liebigs Annalen der Chemie, 1907 , vol. 355, p. 366
Justus Liebigs Annalen der Chemie, 1909 , vol. 371, p. 388
反应条件
1: concentrated sulfuric acid; picric acid / 160 °C
2: iron powder; acetic acid
View Scheme
参考文献
Noelting; Trautmann
Chemische Berichte, 1890 , vol. 23, p. 3655
反应条件
1.1: nitric acid / water; ethanol / 48 h / |Reflux
1.2: 20 °C
2.1: sodium hydroxide / water; butan-1-ol / 18 h / |Reflux
3.1: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
Islam, Rafiqul; Hossain, Md. Imran; Okamoto, Yoshinari; Nagamatsu, Tomohisa; Anraku, Kensaku; Okawara, Tadashi
Heterocycles, 2014 , vol. 89, # 3 p. 693 - 708
反应条件
1: 1.) H2SO4, NaNO2 / 1.) 2-5 deg C, 2.) heating
2: 81 percent / K2CO3 / dimethylformamide / 4 h / Heating
View Scheme
参考文献
Fritzsche, Katharina; Langhals, Heinz
Chemische Berichte, 1984 , vol. 117, # 6 p. 2275 - 2286
反应条件
1: aq. HCl / butan-1-ol / 150 °C
2: H2 / Pd/C / butan-1-ol
View Scheme
参考文献
Manley, Paul W.; Breitenstein, Werner; Brueggen, Josef; Cowan-Jacob, Sandra W.; Furet, Pascal; Mestan, Juergen; Meyer, Thomas
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5793 - 5797
反应条件
sodium amalgam; ethanol; acetic acid
参考文献
Poirrier; Rosenstiehl
Patent: DE44045 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 2, p. 436
