3,4-二羟基-2'-氯苯乙酮合成路线 （共 71 条）
反应条件
1: 86 percent / CF3COOH, Et3SiH / Ambient temperature 2: 57 percent / K2CO3, NaI / acetone / 15 h / Heating 3: 92 percent / tetrahydrofuran; ethanol; methanol / 12 h / Heating 4: 65 percent / EtSH, BF3*Et2O / 1 h / Ambient temperature 5: 62 percent / acetonitrile View Scheme
参考文献
Chang; Ares; Anderson; Sabol; Wallace; Farooqui; Uretsky; Miller
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 214 - 218
反应条件
in 1,4-dioxane T=70 - 80°C; 3 h;
参考文献
NATIONAL RESEARCH COUNCIL OF CANADA
Patent: WO2008/92257 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
triethylamine in tetrahydrofuran T=0°C;
参考文献
Gill; Freeman; Irwin; Wilson
European Journal of Medicinal Chemistry, 1996 , vol. 31, # 11 p. 847 - 859
反应条件
ethanol; sodium carbonate
参考文献
Blicke; Johnson
Journal of the American Pharmaceutical Association (1912-1977), 1956 , vol. 45, p. 440
反应条件
potassium carbonate in acetone 7 h; Heating;
参考文献
Hiratake, Jun; Inagaki, Minoru; Nishioka, Takaaki; Oda, Jun'ichi
Journal of Organic Chemistry, 1988 , vol. 53, # 26 p. 6130 - 6133
反应条件
1: With formic acid; sodium formate in ethanol; water T=100°C; 24 h; 2: With hydrogenchloride; ethanol; water pH=~ 0.5; Heating / reflux; Product distribution / selectivity;
参考文献
DSM IP ASSETS B.V.
Patent: WO2008/107109 A1, 2008 ;
Location in patent: Page/Page column 5 ;
参考文献
Ethyl Corporation
Patent: US5047592 A1, 1991 ;
参考文献
Stolz
Chemische Berichte, 1904 , vol. 37, p. 4151
Full Text Show Details
Hoechster Farbw.
Patent: DE152814 ;
Full Text Show Details
Friedmann
B. Ph. P., 1905 , vol. 6, p. 114,93
反应条件
1: 8-Bromo-3-methyl-3,7-dihydropurine-2,6-dione With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=-25 - 70°C; Inert atmosphere; 2: 3',4'-dihydroxy-2-chloroacetophenone in N,N-dimethyl-formamide T=70°C; 5 h; Inert atmosphere;
参考文献
Lafleur, Karine; Huang, Danzhi; Zhou, Ting; Caflisch, Amedeo; Nevado, Cristina
Journal of Medicinal Chemistry, 2009 , vol. 52, # 20 p. 6433 - 6446
反应条件
pyridine in dichloromethane
参考文献
Shionogi and Co., Ltd.
Patent: US5134138 A1, 1992 ;
