噻吩并[3,2-b!噻吩-2-羧酸甲酯合成路线 （共 13 条）
反应条件
triethylamine in dimethyl sulfoxide; ethyl acetate
参考文献
Eisai Co., Ltd.
Patent: US5340833 A1, 1994 ;
US 5340833 A
反应条件
sodium hydrogencarbonate; acetic acid in water; toluene; benzene
反应条件
1: 92.5 percent / NaOAc / acetic acid / 0.5 h / Heating 2: 93 g / 8 percent NaOH / 0.5 h / 45 - 60 °C 3: Cl2 / 1,1,2-trichloro-ethane / 1.) RT, 1 h, 2.) reflux, 1 h 4: 400 g / HCl / 2 h / Heating View Scheme
参考文献
Journal of medicinal chemistry, , vol. 28, # 12 p. 1896 - 1903
反应条件
1: 93 g / 8 percent NaOH / 0.5 h / 45 - 60 °C 2: Cl2 / 1,1,2-trichloro-ethane / 1.) RT, 1 h, 2.) reflux, 1 h 3: 400 g / HCl / 2 h / Heating View Scheme
参考文献
Journal of medicinal chemistry, , vol. 28, # 12 p. 1896 - 1903
反应条件
1: Cl2 / 1,1,2-trichloro-ethane / 1.) RT, 1 h, 2.) reflux, 1 h 2: 400 g / HCl / 2 h / Heating View Scheme
参考文献
Journal of medicinal chemistry, , vol. 28, # 12 p. 1896 - 1903
反应条件
1: 17.6 g / pyridinium tosylate / toluene / 1 h / Heating 3: p-toluenesulfonic acid hydrate / acetone / 1 h 4: 36.93 g / piperidine, acetic acid / benzene / 5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 6 p. 1805 - 1818
反应条件
2: p-toluenesulfonic acid hydrate / acetone / 1 h 3: 36.93 g / piperidine, acetic acid / benzene / 5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 6 p. 1805 - 1818
反应条件
1: p-toluenesulfonic acid hydrate / acetone / 1 h 2: 36.93 g / piperidine, acetic acid / benzene / 5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 6 p. 1805 - 1818
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Kukolja; Draheim; Graves; Hunden; Pfeil; Cooper; Ott; Counter
Journal of medicinal chemistry, 1985 , vol. 28, # 12 p. 1896 - 1903
参考文献
Journal of the Institute of Petroleum, , vol. 37, p. 396,401
Journal of the Chemical Society, , p. 305,308
