(1S)-1-(2R)-环氧乙基-2-苯乙基氨基甲酸叔丁酯合成路线 （共 74 条）
反应条件
1: propan-2-ol / 2 h / 80 °C 2: 0.88 g / triethylamine / CH2Cl2 / 4 h / 20 °C 3: H2 / Pd(OH)2 on carbon / ethyl acetate / 1 h 4: 0.75 g / trifluoroacetic acid / CH2Cl2 / 20 °C View Scheme
参考文献
Ghosh, Arun K.; Leshchenko, Sofiya; Noetzel, Marcus
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 7822 - 7829
反应条件
1: 84 percent / propan-2-ol / 1.) 70 deg C, 9 h, 2.) r.t., 16 h
2: 86 percent / trifluoroacetic acid / 1 h / Ambient temperature
3: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature
View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
反应条件
2: camphorsulfonic acid, MeOH
View Scheme
参考文献
Askin, D.; Wallace, M. A.; Vacca, J. P.; Reamer, R. A.; Volante, R. P.; Shinkai, I.
Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2771 - 2773
反应条件
1.1: toluene / 2.5 h / Heating
1.2: triethylamine / toluene / Heating
1.3: 70 percent / conc. HCl / toluene / 1.5 h / Heating
2.1: 80 percent / ethyl acetate; ethanol / 17 h / Heating
View Scheme
参考文献
Kim; Bae; So; Yoo; Chang; Lee; Kang
Organic letters, 2001 , vol. 3, # 15 p. 2349 - 2351
