1: 78 percent / Ac2O, pyridine 2: 95 percent / Et3N 3: 98 percent / 10 percent HCl / tetrahydrofuran 4: HN(SiMe3)2 6: DBU / 2-methyl-propan-2-ol / Heating 7: H2 / Raney Ni 8: 80 percent / Mg(OTf)2 9: 73 percent / CHCl3 10: 1.) Et3O(1+)*BF4(1-), Na2CO3; 2.) HOAc / 1.) THF, CH2Cl2 11: 80 percent / ethanol 12: methanolic sodium methoxide / benzene 13: Et3N / CHCl3 / 100 °C / sealed tube View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 100 percent / p-TsOH / benzene / 1 h / Heating<br />2: 91 percent / 2 percent KOH / methanol; 1,2-dimethoxy-ethane; H₂O / 1.5 h / Ambient temperature<br />3: 78 percent / POCl₃ / diethyl ether / 0.5 h / 0 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 91 percent / 2 percent KOH / methanol; 1,2-dimethoxy-ethane; H₂O / 1.5 h / Ambient temperature<br />2: 78 percent / POCl₃ / diethyl ether / 0.5 h / 0 - 20 &deg;C<br /> <br /> &nbsp;