(6CI,9CI)-2-甲基-噻唑并[5,4-c]吡啶合成路线 （共 13 条）
参考文献
Matsumoto, Kouzou; Nishizawa, Maho; Hirao, Yasukazu; Kurata, Hiroyuki; Kubo, Takashi
Heterocycles, 2014 , vol. 88, # 1 p. 175 - 178
反应条件
sodium hydride in various solvent(s)
T=150°C; 1 h;
参考文献
Couture, Axel; Grandclaudon, Pierre; Huguerre, Eric
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1765 - 1770
参考文献
Matsumoto, Kouzou; Nishizawa, Maho; Hirao, Yasukazu; Kurata, Hiroyuki; Kubo, Takashi
Heterocycles, 2014 , vol. 88, # 1 p. 175 - 178
反应条件
1: 36 percent / 1 N NaOH / methanol / 2 h / Ambient temperature
2: 62 percent / HClO4
3: 62 percent / 98percent HCOOH / 4 h / Heating
View Scheme
参考文献
Katner; Brown
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 563 - 566
反应条件
1: 1) n-butyllithium / 1) THF, hexane, -10 to 0 deg C, 2) THF, 0 deg C to room temperature
2: 36 percent / 1 N NaOH / methanol / 2 h / Ambient temperature
3: 62 percent / HClO4
4: 62 percent / 98percent HCOOH / 4 h / Heating
View Scheme
参考文献
Katner; Brown
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 563 - 566
反应条件
trichlorophosphate
4 h; Heating;
参考文献
El-Hiti, Gamal A.
Monatshefte fur Chemie, 2003 , vol. 134, # 6 p. 837 - 841
反应条件
1: 1) C2H5MgBr or BuLi or NaH / 1) THF, reflux; 2) dioxan, reflux, 2 h
2: 54 percent / NaH / various solvent(s) / 1 h / 150 °C
View Scheme
参考文献
Couture, Axel; Grandclaudon, Pierre; Huguerre, Eric
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1765 - 1770
反应条件
1: 62 percent / HClO4
2: 62 percent / 98percent HCOOH / 4 h / Heating
View Scheme
参考文献
Katner; Brown
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 563 - 566
反应条件
1: aqueous HCl; acetic acid
2: sodium acetate
View Scheme
参考文献
Takahashi; Ueda
Pharmaceutical Bulletin, 1956 , vol. 4, p. 216,219
参考文献
Takahashi; Ueda
Pharmaceutical Bulletin, 1956 , vol. 4, p. 216,219
