in N-methyl-acetamide

1: 1.) sodium carbonate / 1.) water, acetone, 5 deg C, 1 h; 2.) 20 deg C, 1 h 2: 93 percent / toluene; acetic anhydride / 2 h / 50 °C 3: 3.) acetic acid / 1.) pyridine, r.t., 1 h; 2.) 50-60 deg C, 2 h; 3.) 55 deg C, 2 h View Scheme

1: 93 percent / toluene; acetic anhydride / 2 h / 50 °C 2: 3.) acetic acid / 1.) pyridine, r.t., 1 h; 2.) 50-60 deg C, 2 h; 3.) 55 deg C, 2 h View Scheme

1: 1.) sodium carbonate / 1.) water, acetone, 5 deg C, 1 h; 2.) 20 deg C, 1 h 2: 93 percent / toluene; acetic anhydride / 2 h / 50 °C 3: 3.) acetic acid / 1.) pyridine, r.t., 1 h; 2.) 50-60 deg C, 2 h; 3.) 55 deg C, 2 h View Scheme

acetic acid 1.) pyridine, r.t., 1 h; 2.) 50-60 deg C, 2 h; 3.) 55 deg C, 2 h; Yield given. Multistep reaction;