2-甲基巯基-4-甲基嘧啶-5-甲酸合成路线 （共 6 条）
反应条件
1: With sodium hydroxide; ethanol; water T=0 - 20°C; 2 h; 2: With hydrogenchloride in water
参考文献
KUMIAI CHEMICAL INDUSTRY CO., LTD.; Ihara Chemical Industry Co., Ltd.
Patent: EP1439169 A1, 2004 ;
Location in patent: Page 97 ;
反应条件
1: With sodium ethanolate in ethanol Heating; 2: With sodium hydroxide in tetrahydrofuran; methanol T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2573 - 2577
反应条件
1: 79 percent / CH3COONa / dimethylformamide / 12 h / 80 - 90 °C 2: 80 percent / 2 N NaOH / Ambient temperature View Scheme
参考文献
Farmaco, , vol. 48, # 3 p. 335 - 355
反应条件
1: ethanolic sodium ethylate 2: ethanolic KOH View Scheme
参考文献
Huaxue Xuebao, , vol. 23, p. 145,150
Scientia Sinica (English Edition), , vol. 6, p. 853
Chem.Abstr., , p. 14626
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355
反应条件
1: (COCl)2 / various solvent(s) / 1 h / 20 °C
2: tetrahydrofuran / 2 h / -78 °C
View Scheme
参考文献
Palanki, Moorthy S.S.; Gayo-Fung, Leah M.; Shevlin, Graziella I.; Erdman, Paul; Sato, Mark; Goldman, Mark; Ransone, Lynn J.; Spooner, Cheryl
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 18 p. 2573 - 2577
