4-(叔丁基)-N,N-二甲基-[1,1-联苯]-4-胺合成路线 （共 7 条）
反应条件
(IPr)Ni(π-allyl)Cl in tetrahydrofuran
T=80°C; Kumada Cross-Coupling; 12 h; Inert atmosphere;
参考文献
Iglesias, Maria Jose; Prieto, Auxiliadora; Nicasio, M. Carmen
Organic Letters, 2012 , vol. 14, # 17 p. 4318 - 4321
反应条件
tetraethylammonium p-toluenesulfonate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
Ambient temperatureelectrolysis;
参考文献
Torii, Sigeru; Tanaka, Hideo; Morisaki, Kazuo
Tetrahedron Letters, 1985 , vol. 26, # 13 p. 1655 - 1658
反应条件
catalyst 1 (aliphatic, phosphine based pincer complex of palladium) in 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; 0.3 h;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 48 p. 12939 - 12941
反应条件
bis(η3-allyl-μ-chloropalladium(II)); 1,4-di(diphenylphosphino)-butane; potassium hydroxide in water; tert-butyl alcohol
T=90°C;
参考文献
Boehner, Christine M.; Frye, Elizabeth C.; O'Connell, Kieron M. G.; Galloway, Warren R. J. D.; Sore, Hannah F.; Dominguez, Patricia Garcia; Norton, David; Hulcoop, David G.; Owen, Martin; Turner, Gillian; Crawford, Claire; Horsley, Helen; Spring, David R.
Chemistry - A European Journal, 2011 , vol. 17, # 47 p. 13230 - 13239
反应条件
1: 4-Me2NC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: 1-bromo-4-(1,1-dimethylethyl)benzene With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
bis-triphenylphosphine-palladium(II) chloride; tetraethylammonium p-toluenesulfonate; triphenylphosphine in N,N-dimethyl-formamide
Ambient temperatureelectroreduction;
参考文献
Amatore, Christian; Carre, Emmanuelle; Jutand, Anny; Tanaka, Hideo; Ren, Qinghua; Torii, Sigeru
Chemistry--A European Journal, 1996 , vol. 2, # 8 p. 957 - 966
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: bis(η3-allyl-μ-chloropalladium(II)); 1,4-di(diphenylphosphino)-butane; potassium hydroxide / water; tert-butyl alcohol / 90 °C
View Scheme
参考文献
Boehner, Christine M.; Frye, Elizabeth C.; O'Connell, Kieron M. G.; Galloway, Warren R. J. D.; Sore, Hannah F.; Dominguez, Patricia Garcia; Norton, David; Hulcoop, David G.; Owen, Martin; Turner, Gillian; Crawford, Claire; Horsley, Helen; Spring, David R.
Chemistry - A European Journal, 2011 , vol. 17, # 47 p. 13230 - 13239
