in ammonium hydroxide Yield given;

ammonia 16 h; Ambient temperature; Yield given;

<b>Multi-step reaction with 6 steps<br /> </b>1: 1.) triethylamine, 2-mesitylenesulfonyl chloride, 4-N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo&lt;2.2.2&gt;octane, triethylamine / 1.) dichloromethane, 20 deg C, 1 h, 2.) dichloromethane, 20 deg C, 1 h<br />2: tetrabutylammonium fluoride / tetrahydrofuran / 0.08 h / 20 &deg;C<br />3: 4-nitrobenzaldoxime, N,N,N',N'-tetramethylguanidine / dioxane; H₂O / 0.05 h / 20 &deg;C<br />4: pyridine / 1 h / 20 &deg;C<br />5: 1.) triethylamine, 2-mesitylenesulfonyl chloride, 4-N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo&lt;2.2.2&gt;octane, triethylamine / 1.) dichloromethane, 20 deg C, 1 h, 2.) dichloromethane, 20 deg C, 1 h<br />6: 96 percent / triethylamine / ethanol / 0.02 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 4-nitrobenzaldoxime, N,N,N',N'-tetramethylguanidine / dioxane; H₂O / 0.05 h / 20 &deg;C<br />2: pyridine / 1 h / 20 &deg;C<br />3: 1.) triethylamine, 2-mesitylenesulfonyl chloride, 4-N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo&lt;2.2.2&gt;octane, triethylamine / 1.) dichloromethane, 20 deg C, 1 h, 2.) dichloromethane, 20 deg C, 1 h<br />4: 96 percent / triethylamine / ethanol / 0.02 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 4-nitrobenzaldoxime, N,N,N',N'-tetramethylguanidine / dioxane; H₂O / 0.05 h / 20 &deg;C<br />2: pyridine / 1 h / 20 &deg;C<br />3: 1.) triethylamine, 2-mesitylenesulfonyl chloride, 4-N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo&lt;2.2.2&gt;octane, triethylamine / 1.) dichloromethane, 20 deg C, 1 h, 2.) dichloromethane, 20 deg C, 1 h<br />4: 96 percent / triethylamine / ethanol / 0.02 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 4-nitrobenzaldoxime, N,N,N',N'-tetramethylguanidine / dioxane; H₂O / 0.05 h / 20 &deg;C<br />2: pyridine / 1 h / 20 &deg;C<br />3: 1.) triethylamine, 2-mesitylenesulfonyl chloride, 4-N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo&lt;2.2.2&gt;octane, triethylamine / 1.) dichloromethane, 20 deg C, 1 h, 2.) dichloromethane, 20 deg C, 1 h<br />4: 96 percent / triethylamine / ethanol / 0.02 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 4-nitrobenzaldoxime, N,N,N',N'-tetramethylguanidine / dioxane; H₂O / 0.05 h / 20 &deg;C<br />2: pyridine / 1 h / 20 &deg;C<br />3: 1.) triethylamine, 2-mesitylenesulfonyl chloride, 4-N,N-dimethylaminopyridine, 2.) 1,4-diazabicyclo&lt;2.2.2&gt;octane, triethylamine / 1.) dichloromethane, 20 deg C, 1 h, 2.) dichloromethane, 20 deg C, 1 h<br />4: 96 percent / triethylamine / ethanol / 0.02 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 92 percent / pyridine / 3 h / 60 &deg;C<br />2: 65 percent / 4-chlorophenyldichlorophosphate / pyridine / 18 h / Ambient temperature<br />3: ethanol / Ambient temperature<br /> <br /> &nbsp;