2-氨基-5-溴-4-甲基吡啶合成路线 （共 25 条）
反应条件
in water; N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US5972975 A1, 1999 ;
反应条件
1: 1.) NaNO2, 20 percent sulphuric acid / 1.) 0 deg C, 1 h; 2.) 1 h, reflux 2: 74 percent / silver carbonate / benzene / 3 h / 60 °C View Scheme
参考文献
Pearson, Neil D.; Broom, Nigel J.P.; O'Hanlon, Peter J.
Tetrahedron Letters, 1994 , vol. 35, # 22 p. 3771 - 3774
反应条件
1: With N-iodo-succinimide; trifluoroacetic acid in acetic acid T=20°C; 2.5 h; 2: With ammonia in water Cooling;
参考文献
Daiichi Sankyo Company, Limited
Patent: US2011/82138 A1, 2011 ;
Location in patent: Page/Page column 32 ;
US 20110082138 A1
反应条件
sulfuric acid; dihydrogen peroxide in water T=20°C; Cooling with ice;
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel, L.; PETILLO, Peter, A.; KAUFMAN, Michael, D.
Patent: WO2010/51373 A1, 2010 ;
Location in patent: Page/Page column 77 ;
WO 2010/051373 A1
反应条件
1.1: sodium nitrite; concd. hydrochloric acid / 1 h / -20 °C
1.2: 48 percent / aq. sodium hydroxide / 0 - 5 °C / pH 11
2.1: 47 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / Heating
View Scheme
参考文献
Cheng, Jie; Xu, Liang; Stevens, Edwin D.; Trudell, Mark L.; Izenwasser, Sari; Wade, Dean
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 4 p. 569 - 574
