2-氨基-5-溴-4-甲基吡啶合成路线 （共 25 条）
反应条件
1: With 1,3-dibromo-5,5-dimethyl-hydantoin in dichloromethane T=-45°C; 0.5 h; 2: With sodium hydrogencarbonate in dichloromethane; water T=-45 - 22°C;
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
bromine in acetic acid T=20°C; 1 h;
参考文献
Heterocycles, , vol. 38, # 3 p. 529 - 540
反应条件
hydrogen bromide; dihydrogen peroxide T=70°C; 1 h; Product distribution;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. 331, # 3 p. 369 - 374
反应条件
in acetonitrile 2 h; Reflux;
参考文献
PIRAMAL LIFE SCIENCES LIMITED; KUMAR, Sanjay; HARIHARAN, Sivaramakrishnan; BHONDE, Mandar; DAGIA, Nilesh; SHARMA, Rajiv; MANE, Pallavi Hanmantrao; KUMAR, Pramod Bhaskar
Patent: WO2011/55320 A1, 2011 ;
Location in patent: Page/Page column 46-47 ;
WO 2011/055320 A1
反应条件
1: With hydrogen bromide; bromine; sodium nitrite in water T=0 - 5°C; 1 h; 2: With sodium hydroxide in water pH=~ 13;
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2008/124610 A1, 2008 ;
Location in patent: Page/Page column 46 ;
WO 2008/124610 A1
反应条件
1.1: sulfuric acid; nitric acid / -10 - 22 °C 2.1: sulfuric acid / 2 h / 22 °C 2.2: 22 °C 3.1: hydrogenchloride; tin(ll) chloride / water / 0 - 100 °C 4.1: 1 h / Erfllectrochemical reaction View Scheme
参考文献
Wu, Runzhi; Smidansky, Eric D.; Oh, Hyung Suk; Takhampunya, Ratree; Padmanabhan, Radhakrishnan; Cameron, Craig E.; Peterson, Blake R.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7958 - 7966
反应条件
1: concentrated H2SO4; concentrated HNO3 2: SnCl2; aqueous HCl View Scheme
参考文献
Daiichi Sankyo Company, Limited
Patent: US2011/82138 A1, 2011 ;
US 20110082138 A1
反应条件
1: concentrated H2SO4; concentrated HNO3 2: SnCl2; aqueous HCl 3: aqueous HCl; NaNO2 4: palladium/charcoal; platinum; aq. NaOH solution / Hydrogenation View Scheme
参考文献
Graboyes; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 6421,6423,6424
反应条件
1: With NOBF4 in chloroform T=0 - 20°C; 2 h; 2: in dimethyl sulfoxide T=150°C;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1726590 A1, 2006 ;
Location in patent: Page/Page column 66 ;
反应条件
1: With hydrogenchloride; sodium nitrite T=-20°C; 1 h; 2: With sodium hydroxide T=0 - 5°C; pH=11;
参考文献
Cheng, Jie; Xu, Liang; Stevens, Edwin D.; Trudell, Mark L.; Izenwasser, Sari; Wade, Dean
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 4 p. 569 - 574
