7-氯-6-氟-1-对氟苯基-1,4-二氢-4-氧代-3-喹啉羧酸合成路线 （共 14 条）
反应条件
sodium hydroxide in tetrahydrofuran T=80°C; 1.5 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1558 - 1564
反应条件
hydrogen fluoride; sodium nitrite in pyridine a) Dissolving in HF and pyridine at 0 deg C and then 30 min at room temperature b) Sodium nitrite was added at 0 deg C c) Then 30 min at 30 deg C and 3h at 70 deg C;
参考文献
Radl, Stanislav; Zikan, Viktor
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 8 p. 2181 - 2189
反应条件
1: 80 percent / NaH / 1.5 h / 80 °C 2: Ac2O / 2 h / 130 °C 3: CH2Cl2 / 0.5 h / Ambient temperature 4: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C 5: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1558 - 1564
反应条件
1: Ac2O / 2 h / 130 °C 2: CH2Cl2 / 0.5 h / Ambient temperature 3: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C 4: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1558 - 1564
反应条件
1: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C 2: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1558 - 1564
反应条件
1: CH2Cl2 / 0.5 h / Ambient temperature 2: NaH / 1,2-dimethoxy-ethane / 3 h / 80 °C 3: aq. NaOH / tetrahydrofuran / 1.5 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1558 - 1564
反应条件
1: 61 percent / K2CO3 / dimethylformamide / 15 h / 100 °C 2: NaOH , FeSO4 / 1) aq NaOH,reflux,4 h 2) reflux 30 min 3: 54 percent / Hydrogen fluoride, Sodium nitrite / pyridine / a) Dissolving in HF and pyridine at 0 deg C and then 30 min at room temperature b) Sodium nitrite was added at 0 deg C c) Then 30 min at 30 deg C and 3h at 70 deg C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 54, # 8 p. 2181 - 2189
反应条件
1: NaOH , FeSO4 / 1) aq NaOH,reflux,4 h 2) reflux 30 min 2: 54 percent / Hydrogen fluoride, Sodium nitrite / pyridine / a) Dissolving in HF and pyridine at 0 deg C and then 30 min at room temperature b) Sodium nitrite was added at 0 deg C c) Then 30 min at 30 deg C and 3h at 70 deg C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 54, # 8 p. 2181 - 2189
反应条件
1: 61 percent / K2CO3 / dimethylformamide / 15 h / 100 °C 2: NaOH , FeSO4 / 1) aq NaOH,reflux,4 h 2) reflux 30 min 3: 54 percent / Hydrogen fluoride, Sodium nitrite / pyridine / a) Dissolving in HF and pyridine at 0 deg C and then 30 min at room temperature b) Sodium nitrite was added at 0 deg C c) Then 30 min at 30 deg C and 3h at 70 deg C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 54, # 8 p. 2181 - 2189
反应条件
1: 86 percent / Sodium hydroxide, Ferrous sulfate / H2O / 0.5 h / Heating 2: 54 percent / Hydrogen fluoride, Sodium nitrite / pyridine / a) Dissolving in HF and pyridine at 0 deg C and then 30 min at room temperature b) Sodium nitrite was added at 0 deg C c) Then 30 min at 30 deg C and 3h at 70 deg C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 54, # 8 p. 2181 - 2189
