2-甲酸吡嗪合成路线

参考文献

Sunami, Satoshi; Sagara, Takeshi; Ohkubo, Mitsuru; Morishima, Hajime
Tetrahedron Letters, 1999 , vol. 40, # 9 p. 1721 - 1724

98-97-52-甲酸吡嗪→39204-47-22-氯甲基吡嗪

参考文献

ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;

98-97-52-甲酸吡嗪+501-53-1氯甲酸苄酯→191739-36-31,4-双(苄氧基羰基)哌嗪-2-羧酸

参考文献

PHARMACIA and UPJOHN COMPANY
Patent: EP874852 B1, 2004 ;
Location in patent: Page 10 ;

98-97-52-甲酸吡嗪+10025-87-3三氯氧磷→23688-89-36-氯吡嗪-2-羧酸

参考文献

Servusova, Barbora; Paterova, Pavla; Mandikova, Jana; Kubicek, Vladimir; Kucera, Radim; Kunes, Jiri; Dolezal, Martin; Zitko, Jan
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 450 - 453

98-97-52-甲酸吡嗪→98-96-4吡嗪酰胺

参考文献

Reddy, Ch. Sanjeeva; Raghu; Nagaraj
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008 , vol. 47, # 2 p. 315 - 318

98-97-52-甲酸吡嗪→19847-10-0吡嗪-2-甲酰氯

参考文献

Cynamon, Michael H.; Gimi, Rayomand; Gyenes, Ferenc; Sharpe, Cindy A.; Bergmann, Kathryn E.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 3902 - 3907

98-97-52-甲酸吡嗪→205393-22-2保特佐米蒎烷二醇酯

参考文献

CIPLA LIMITED; KING, Lawrence, Louis; RAO, Dharmaraj, Ramachandra; KANKAN, Rajendra, Narayanrao; PATHI, Srinivas, Laxminarayan; PUPPALA, Ravikumar
Patent: WO2014/41324 A1, 2014 ;
Location in patent: Page/Page column 14 ;

98-97-52-甲酸吡嗪+205393-21-1(alphaS)-alpha-氨基-N-[(1R)-1-[(3aS,4S,6S,7aR)-六氢-3a,5,5-三甲基-4,6-甲桥-1,3,2-苯并二氧硼烷-2-基]-3-甲基丁基]苯丙酰胺盐酸盐→205393-22-2保特佐米蒎烷二醇酯

参考文献

MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2005/97809 A2, 2005 ;
Location in patent: Page/Page column 46-48 ;
WO 2005/097809 A2

98-97-52-甲酸吡嗪+789472-91-9→205393-22-2保特佐米蒎烷二醇酯

参考文献

Milo, Lawrence J.; Lai, Jack H.; Wu, Wengen; Liu, Yuxin; Maw, Hlaing; Li, Youhua; Jin, Zhiping; Shu, Ying; Poplawski, Sarah E.; Wu, Yong; Sanford, David G.; Sudmeier, James L.; Bachovchin, William W.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4365 - 4377

98-97-52-甲酸吡嗪→205393-22-2保特佐米蒎烷二醇酯

参考文献

SYNTHON BV; CASTULIK, Jakub; ZABADAL, Miroslav
Patent: WO2012/48745 A1, 2012 ;