2-羟基-4-甲基苯甲醛合成路线 （共 34 条）
反应条件
1: 90 percent / sulfuric acid / 2 h / 105 °C
2: 80 percent / potassium carbonate / acetonitrile / 144 h / 90 °C
3: 82 percent / nitric acid; acetic acid / CH2Cl2 / 2 h
4: 72 percent / H2 / Raney nickel / tetrahydrofuran; ethanol / 24 h / 20 °C
View Scheme
参考文献
Rudzevich, Valentyn; Schollmeyer, Dieter; Braekers, Damien; Desreux, Jean F.; Diss, Romain; Wipff, Georges; Boehmer, Volker
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6027 - 6033
反应条件
1: conc. HCl / 6 h / 90 - 100 °C
2: aq. KOH, H2 / Raney-nickel / methanol / 1.) 3 - 4 h, RT, 2.) 60 deg C
View Scheme
参考文献
Boehmer, Volker; Stotz, Diethard; Beismann, Klaus; Vogt, Walter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 65 - 78
反应条件
1: bromine / aq. acetic acid
2: bromine / aq. acetic acid / 0.5 h
3: H2SO4 / 0.17 h
View Scheme
参考文献
Brittain, Judith M.; Mare, Peter B. D. de la; Newman, Paul A.; Chin, Wong See
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1982 , p. 1193 - 1198
反应条件
1: (bromination)
2: (CF3CO2)3Tl
View Scheme
参考文献
McKillop,A. et al.
Tetrahedron, 1970 , vol. 26, p. 4031 - 4039
