1.1: Novozyme.(R). 435 / di-isopropyl ether; water / 12 h / 70 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C / Inert atmosphere 3.1: tris-(dibenzylideneacetone)dipalladium(0); methyl-ethyl phosphite / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere 4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; dichloromethane / 0.5 h / Inert atmosphere 5.1: sodium tetrahydroborate; isopropyl alcohol / tetrahydrofuran / 1 h / 0 °C 6.1: ethanol / 5 h / 50 °C 7.1: dimethyl sulfoxide / 150 °C 8.1: trifluoroacetic acid / chloroform / 72 h / 50 °C / Inert atmosphere View Scheme