2-氨基-5-碘三氟甲基苯合成路线 （共 10 条）
反应条件
iodine cloride in dichloromethane 12 h;
参考文献
WO2006/101318 A1, ;
Page/Page column 98 ;
WO 2006/101318 A1
反应条件
[iridium(III)(2-phenylpyridine)3] in N,N-dimethyl-formamide T=20°C; Inert atmosphereIrradiationSchlenk technique;
参考文献
Organic Letters, , vol. 16, # 6 p. 1768 - 1771
反应条件
1: 89 percent / toluene / 5 h / Heating 2: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C 3: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: 89 percent / toluene / 5 h / Heating 2: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C 3: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating 4: 56 percent / SO2Cl2 / CHCl3 / 8 h / Heating View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
in toluene 5 h; Heating;
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide 12 h;
参考文献
Amorepacific Corporation
Patent: EP1862454 A1, 2007 ;
Location in patent: Page/Page column 12 ;
EP 1862454 A1
反应条件
1: 89 percent / toluene / 5 h / Heating 2: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C 3: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating 4: 56 percent / SO2Cl2 / CHCl3 / 8 h / Heating 5: SOCl2 / 2 h / Heating View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: 89 percent / toluene / 5 h / Heating 2: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1: 89 percent / toluene / 5 h / Heating
2: 71 percent / hexamethylphosphoric acid triamide / 3 h / 150 °C
3: 78 percent / 50percent NaOH / H2O; ethanol / 5 h / Heating
4: 63 percent / Br2 / acetic acid
View Scheme
参考文献
Kruger; Keck; Noll; Pieper
Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 11 A p. 1612 - 1624
反应条件
1.1: 95 percent / BF3*Et2O; t-BuONO / tetrahydrofuran / 0.5 h / -20 - 5 °C
2.1: propylaminomethyl polystyrene; K2CO3 / tetrahydrofuran; dimethylformamide / 1.08 h / 0 - 20 °C
2.2: 37 mg / CH3I / acetonitrile / 24 h / 110 °C
View Scheme
参考文献
Hwang, Jiunn-Jye; Tour, James M.
Tetrahedron, 2002 , vol. 58, # 52 p. 10387 - 10405
