2-(1’-咪唑磺酰氧基)-1,3,5-三苯甲酰氧基-alpha-D-呋喃核糖合成路线 （共 5 条）
反应条件
1: 2,3,5-tri-O-benzoyl-α-D-ribofuranose With thionyl chloride; N,N-dimethyl-formamide in dichloromethane T=-15 - 20°C; 2: 1H-imidazole in dichloromethane T=0 - 20°C;
参考文献
Zhengzhou University; Analyse Testing And Research Center Of Henan Province
Patent: EP2177527 A1, 2010 ;
Location in patent: Page/Page column 11 ;
反应条件
triethylamine tris(hydrogen fluoride) in ethyl acetate T=60 - 70°C; 4.5 h;
参考文献
EP2177527 A1, ;
Page/Page column 11-12 ;
反应条件
KHF2; hydrogen fluoride in various solvent(s) T=160°C; 1 h;
参考文献
Journal of Organic Chemistry, , vol. 50, # 19 p. 3644 - 3647
反应条件
KHF2; hydrogen fluoride in various solvent(s) T=160°C; 1 h; other reaction conditions; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 50, # 19 p. 3644 - 3647
反应条件
1: 62.8 percent / KHF2, 50percent aq. HF / various solvent(s) / 1 h / 160 °C 2: 98 percent / HBr / CH2Cl2; acetic acid / 16 h / Ambient temperature 3: NaI / CH2Cl2; acetonitrile / 168 h / Ambient temperature 4: 90 percent / aq. NaOH / methanol / 16 h View Scheme
参考文献
Tann, Chou H.; Brodfuehrer, Paul R.; Brundidge, Steven P.; Sapino, Chester; Howell, Henry G.
Journal of Organic Chemistry, 1985 , vol. 50, # 19 p. 3644 - 3647
