5-溴-2-氰基吡啶合成路线

参考文献

WO2013/13815 A1, ;

Page/Page column 228 ;
WO 2013/013815 A1

856866-72-33-[3-氟-4-[6-(2-甲基-2H-四唑-5-基)-3-吡啶基]苯基]-5-(羟基甲基)-2-恶唑烷酮

参考文献

Im, Weon Bin; Choi, Sun Ho; Park, Ju-Young; Choi, Sung Hak; Finn, John; Yoon, Sung-Hwa
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1027 - 1039

97483-77-75-溴-2-氰基吡啶

88139-91-75-溴-2-羟甲基吡啶

参考文献

Gruenenthal GmbH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: US2013/29962 A1, 2013 ;

97483-77-75-溴-2-氰基吡啶+

73183-34-3联硼酸频那醇酯

741709-63-72-氰基吡啶-5-硼酸频那酯

参考文献

Patrick, Donald A.; Ismail, Mohamed A.; Arafa, Reem K.; Wenzler, Tanja; Zhu, Xiaohua; Pandharkar, Trupti; Jones, Susan Kilgore; Werbovetz, Karl A.; Brun, Reto; Boykin, David W.; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5473 - 5494

24424-99-5二碳酸二叔丁酯+

97483-77-75-溴-2-氰基吡啶

1188477-11-3(5-溴吡啶-2-甲基)氨基甲酸叔丁酯

参考文献

Curtis, Michael; Duclos, Brian A.; Ewin, Richard A.; Johnson, Paul D.; Johnson, Timothy Allen; Vairagoundar, Rajendran; Billen, Denis; Goodwin, Richard M.; Haber-Stuk, Andrea K.; Kyne, Graham M.; Sheehan, Susan M. K.
Patent: US2013/237502 A1, 2013 ;
Location in patent: Paragraph 0367 ;

97483-77-75-溴-2-氰基吡啶

137178-88-25-溴吡啶-2-甲酰氯

参考文献

Kulkarni, Santosh S.; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 2074 - 2079

97483-77-75-溴-2-氰基吡啶

173999-23-02-(氨甲基)-5-溴吡啶

参考文献

EPIZYME, INC.; DUNCAN, Kenneth, W.; CHESWORTH, Richard; MUNCHHOF, Michael, John; JIN, Lei
Patent: WO2014/100695 A1, 2014 ;
Location in patent: Paragraph 00448 ;

75-16-1甲基溴化镁+

97483-77-75-溴-2-氰基吡啶

214701-49-22-乙酰基-5-溴吡啶

参考文献

ASTRAZENECA UK LIMITED
Patent: WO2005/116023 A1, 2005 ;
Location in patent: Page/Page column 44-45 ;
WO 2005/116023 A1

676-58-4甲基氯化镁+

97483-77-75-溴-2-氰基吡啶

214701-49-22-乙酰基-5-溴吡啶

参考文献

Housey, Gerad M.
Patent: US2010/16298 A1, 2010 ;
Location in patent: Page/Page column 202 ;

97483-77-75-溴-2-氰基吡啶

1211584-19-85-乙炔氰基吡啶

参考文献

Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Wenzler, Tanja; Brun, Reto; Tidwell, Richard R.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 559 - 576