2-[2-(三甲基硅烷基)乙炔基]-苯甲腈合成路线 （共 12 条）
反应条件
potassium carbonate in methanol T=20°C; 15 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 49, # 7 p. 1278 - 1281
反应条件
potassium carbonate T=120 - 130°C; 0.25 h; microwave irradiation;
参考文献
Tetrahedron Letters, , vol. 44, # 41 p. 7611 - 7612
反应条件
1: ethanol / 6 h / Heating 2: 74 percent / 3N Na2CO3, 15percent H2O2 / acetone / 4 h / Ambient temperature 3: 82 percent / TsOH / benzene / 8 h / Heating View Scheme
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 626 - 633
反应条件
methanol; water; potassium carbonate in tetrahydrofuran T=20°C; 6 h;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2005/82898 A1, 2005 ;
Location in patent: Page/Page column 62 ;
反应条件
copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=65°C; Castro-Stephens/Sonogashira coupling; 60 h;
参考文献
Wang, Xianghua; Dong, Shuli; Yao, Zhili; Feng, Lei; Daka, Philias; Wang, Hong; Xu, Zhenghu
Organic Letters, 2014 , vol. 16, # 1 p. 22 - 25
反应条件
N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in 1,4-dioxane
T=60°C; Sonogashira Coupling; 5 h;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2005/82898 A1, 2005 ;
Location in patent: Page/Page column 62 ;
参考文献
KAOHSIUNG MEDICAL UNIVERSITY
Patent: US2005/4211 A1, 2005 ;
Location in patent: Page/Page column 13; 15 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran
T=20°C; Sonogashira Cross-Coupling; 12 h; Inert atmosphere;
参考文献
Varela-Fernandez, Alejandro; Varela, Jesus A.; Saa, Carlos
Synthesis (Germany), 2012 , vol. 44, # 21 art. no. SS-2012-Z0414-PSP, p. 3285 - 3295
反应条件
1: trimethylsilylacetylene With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran
T=0°C; Inert atmosphere;
2: 2-cyanophenyl magnesium chloride With oxygen; lithium chloride; manganese (II) chloride in tetrahydrofuran
T=-5 - 0°C;
参考文献
Cahiez, Gerard; Gager, Olivier; Buendia, Julien
Angewandte Chemie - International Edition, 2010 , vol. 49, # 7 p. 1278 - 1281
反应条件
1: 58 percent / Pd
2: 45 percent / Pd(0)
View Scheme
参考文献
Wu, Ming-Jung; Lin, Chi-Fong; Chen, Shang-Hung
Organic Letters, 1999 , vol. 1, # 5 p. 767 - 768
