(R)-(+)-α-烯丙基丙氨酸合成路线 （共 14 条）
反应条件
1: With sodium hydroxide; (R,R)-N,N'-bis(salicylidene)-1,2-cyclohexanediaminocopper(II) in toluene T=20°C; Alkylation; 12 h; 2: With hydrogenchloride Hydrolysis;
参考文献
Belokon, Yuri N.; North, Michael; Kublitski, Vadim S.; Ikonnikov, Nikolai S.; Krasik, Pavel E.; Maleev, Viktor I.
Tetrahedron Letters, 1999 , vol. 40, # 33 p. 6105 - 6108
反应条件
1: CF3COOH 2: Li/NH3 / tetrahydrofuran; 2-methyl-propan-2-ol 3: 6 N hydrochloric acid / tetrahydrofuran; H2O / 110 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 109, # 21 p. 6537 - 6538
反应条件
1: With sodium hydroxide; tetraethylammonium bromide; (-)-(R,R)-TADDOL in toluene T=15 - 20°C; Substitution; 12 h; 2: With hydrogenchloride in water Hydrolysis; 0.25 h; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 65, # 21 p. 7041 - 7048
反应条件
1: With sodium hydroxide; chiral Cu(ch-salen) in toluene T=20°C; 2: in acidic aq. solution Heating; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 42, # 45 p. 8093 - 8096
反应条件
1: With sodium hydroxide; chiral Cu(ch-salen) in toluene T=20°C; 2: in acidic aq. solution Heating; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 42, # 45 p. 8093 - 8096
反应条件
T=37°C; Mycobacterium neoarum ATCC 25795, pH 8-8.5; Yield given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 4, # 6 p. 1113 - 1116
反应条件
Mycobacterium neoaurum ATCC 25795 in water; acetic acid T=40°C; pH=8.0 - 8.5; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 57, # 30 p. 6567 - 6578
反应条件
1: (R)-alanine With (R)-3-FBPB; sodium methylate; nickel(II) nitrate hexahydrate in methanol T=50°C; 2: allyl bromide With sodium hydroxide in N,N-dimethyl-formamide T=45 - 50°C; 0.15 h; Inert atmosphere; optical yield given as percent eeenantioselective reactionFurther stages;
参考文献
Tetrahedron Asymmetry, , vol. 21, # 24 p. 2956 - 2965
反应条件
1: With sodium hydroxide; (-)-(R,R)-TADDOL in toluene T=15 - 20°C; Alkylation; 12 h; 2: With hydrogenchloride in water; toluene Hydrolysis; Heating; Title compound not separated from byproducts;
参考文献
Russian Chemical Bulletin, , vol. 48, # 5 p. 917 - 923
反应条件
hydrogenchloride; water in tetrahydrofuran 3 h; Ambient temperature; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Synthesis, , # 4 p. 704 - 717
