(S)-(-)-α-烯丙基丙氨酸合成路线 （共 18 条）
反应条件
1: With sodium hydroxide in water T=20°C; 2: With bromine in water T=0 - 75°C; Hofmann rearrangement; 4.5 h; 3: With hydrogenchloride in water
参考文献
Zhang, Li-Bin; Wang, De-Xian; Wang, Mei-Xiang
Tetrahedron, 2011 , vol. 67, # 31 p. 5604 - 5609
反应条件
1: With sodium hydroxide in methanol; acetone T=20°C; 2 h; 2: With hydrogenchloride T=92°C; 3 h;
参考文献
Xu, Peng-Fei; Li, Shuo; Lu, Ta-Jung; Wu, Chen-Chang; Fan, Botao; Golfis, Georgia
Journal of Organic Chemistry, 2006 , vol. 71, # 12 p. 4364 - 4373
反应条件
1: With CsOH; water T=70°C; 2 h; 2: With hydrogenchloride in water
参考文献
Lu, Ta-Jung; Lin, Cheng-Kun
Journal of Organic Chemistry, 2011 , vol. 76, # 6 p. 1621 - 1633
反应条件
1: With sodium hydroxide; tetraethylammonium bromide; (-)-(R,R)-TADDOL in toluene T=15 - 20°C; Substitution; 12 h; 2: With hydrogenchloride in water Hydrolysis; 0.25 h; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 65, # 21 p. 7041 - 7048
反应条件
hydrogenchloride T=145°C; 2 h;
参考文献
Frauer, Alexandra; Mehlfuehrer, Michaela; Thirring, Klaus; Berner, Heinz
Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4215 - 4222
反应条件
hydrogenchloride; Dowex 50X-100; acetic acid in toluene Hydrolysis; 96 h; Heating;
参考文献
Najera, Carmen; Abellan, Tomas; Sansano, Jose M.
European Journal of Organic Chemistry, 2000 , # 15 p. 2809 - 2820
反应条件
1: With sodium hydroxide; chiral Cu(ch-salen) in toluene T=20°C; 2: in acidic aq. solution Heating; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 42, # 45 p. 8093 - 8096
反应条件
1: With sodium hydroxide; chiral Cu(ch-salen) in toluene T=20°C; 2: in acidic aq. solution Heating; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 42, # 45 p. 8093 - 8096
反应条件
water in 1,4-dioxane T=100°C; 1 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 15, # 12 p. 3134 - 3137
反应条件
T=37°C; Mycobacterium neoarum ATCC 25795, pH 8-8.5; Yield given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 4, # 6 p. 1113 - 1116
