(S)-1-苯基-1,3-丙二醇合成路线 （共 41 条）
反应条件
1: With trimethylsilyl trifluoromethanesulfonate; 1,1,1,3,3,3-hexamethyl-disilazane 2: With trimethylsilyl trifluoromethanesulfonate; (-)-menthone 3: With hydrogenchloride in methanol
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 7 p. 2178 - 2189
反应条件
sodium tetrahydroborate Yield given;
参考文献
Tetrahedron Letters, , vol. 26, # 3 p. 351 - 354
反应条件
sodium hydroxide; borane-THF; dihydrogen peroxide 1.) CH2Cl2, -45 deg C; Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 34, # 50 p. 8155 - 8156
反应条件
1: 93 percent / pyridine, 4-dimethylaminopyridine / 3 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 19 p. 2477 - 2486
反应条件
1: With C15H19N2O2(1+)*F6P(1-); (S)-bis{4-[(dioctylamino)methyl]phenyl}(pyrrolidin-2-yl)methanol T=25°C; 96 h; Green chemistry; 2: With sodium tetrahydroborate in methanol T=0°C; 0.5 h; Green chemistry; Catalytic behavior; Overall yield = 35 percent; Overall yield = 21.3 mg; enantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 78, # 6 p. 2693 - 2696
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 30, # 50 p. 7121 - 7124
反应条件
Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 19 p. 2477 - 2486
反应条件
1.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 2.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C 2.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C 3.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C View Scheme
参考文献
Gao, Y.; Sharpless, K. B.
Journal of Organic Chemistry, 1988 , vol. 53, # 17 p. 4081 - 4084
反应条件
1.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 2.1: DEAD; PPh3 / diethyl ether; toluene / 30 h / -10 °C 2.2: 78 percent / diethyl ether; toluene / 2.5 h / -10 °C 3.1: 82 percent / H2O; tetrahydrofuran / 4 h / 60 - 65 °C 4.1: 99 percent / HCl / diethyl ether View Scheme
参考文献
Xu, Chengfu; Yuan, Chengye
Tetrahedron, 2005 , vol. 61, # 8 p. 2169 - 2186
反应条件
1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 2: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme
参考文献
Chenevert, Robert; Fortier, Genevieve; Rhlid, Rachid Bel
Tetrahedron, 1992 , vol. 48, # 33 p. 6769 - 6776
