2-氨基-6-氯-4-苯基-吡啶-3,5-二甲腈合成路线 （共 8 条）
反应条件
2,2-dimethyl-1-nitro-propane; copper dichloride in acetonitrile T=65°C; Sandmeyer-type reaction; 8 h;
参考文献
Chioua, Mourad; Samadi, Abdelouahid; Soriano, Elena; Lozach, Olivier; Meijer, Laurent; Marco-Contelles, Jose
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 16 p. 4566 - 4569
参考文献
Little et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 2832,2834
反应条件
sodium hydrogensulfide in ethanol 24 h; Ambient temperature;
参考文献
Quintela, Jose Maria; Peinador, Carlos; Veiga, Mari Carmen; Botana, Luis M.; Alfonso, Amparo; Riguera, Ricardo
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 11 p. 887 - 897
反应条件
1: 2-benzoyl-propanedinitrile With phosphorus pentachloride in dichloromethane
Heating / reflux;
2: malononitrile sodium salt in ethanol
T=0°C; 24 h;
3: With hydrogenchloride in water; acetone
T=50°C; 4.5 h;
参考文献
Harada, Hironori; Watanuki, Susumu; Takuwa, Tomofumi; Kawaguchi, Kenichi; Okazaki, Toshio; Hirano, Yuusuke; Saitoh, Chikasi
Patent: US2003/232860 A1, 2003 ;
Location in patent: Page 15 ;
反应条件
phosphorus pentachloride in ethanol; dichloromethane; acetone
参考文献
YAMANOUCHI PHARMACEUTICAL CO. LTD.
Patent: EP1302463 A1, 2003 ;
反应条件
1: in pyridine
T=110°C; 7 h;
2: With hydrogenchloride in pyridine; water
T=100°C; 2.5 h;
参考文献
Chioua, Mourad; Soriano, Elena; Samadi, Abdelouahid; Marco-Contelles
Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 4 p. 861 - 872
反应条件
phosphorus pentachloride; trichlorophosphate
24 h; Heating;
参考文献
Peinador, Carlos; Veiga, M. Carmen; Vilar, Juan; Quintela, Jose M.
Heterocycles, 1994 , vol. 38, # 6 p. 1299 - 1306
参考文献
Little et al.
Journal of the American Chemical Society, 1958 , vol. 80, p. 2832,2834
