lithium aluminium tetrahydride in tetrahydrofuran Reduction; 48 h; Heating;

hydrogen; palladium on activated charcoal in ethyl acetate 24 h; Ambient temperature;

sodium hydroxide in ethanol 72 h; Heating;

1: 96 percent / pyridine / 2 h / 0 °C 2: 51 percent / Na2CO3 / acetonitrile / 40 h / Heating 3: 90 percent / tetrahydrofuran / 2 h / 60 °C 4: 89 percent / aq.NaOH / ethanol / 72 h / Heating View Scheme

1: 77 percent / K2CO3 / dimethylformamide / 96 h / Heating 2: 96 percent / pyridine / 2 h / 0 °C 3: 51 percent / Na2CO3 / acetonitrile / 40 h / Heating 4: 90 percent / tetrahydrofuran / 2 h / 60 °C 5: 89 percent / aq.NaOH / ethanol / 72 h / Heating View Scheme

1: 51 percent / Na2CO3 / acetonitrile / 40 h / Heating 2: 90 percent / tetrahydrofuran / 2 h / 60 °C 3: 89 percent / aq.NaOH / ethanol / 72 h / Heating View Scheme