3-羟基甲基吲哚-1-羧酸叔丁酯合成路线 （共 11 条）
反应条件
sodium tetrahydroborate in ethanol T=20°C; 6 h;
参考文献
Schoellkopf, Ulrich; Lonsky, Ralph; Lehr, Philipp
Liebigs Annalen der Chemie, 1985 , # 2 p. 413 - 417
反应条件
diisobutylaluminium hydride in tetrahydrofuran; toluene T=0°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1559422 A1, 2005 ;
Location in patent: Page/Page column 130 ;
EP 1559422 A1
反应条件
1: With 4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 2: With sodium tetrahydroborate in methanol T=0 - 20°C; 1.16667 h; 3: With water in methanol
参考文献
WO2008/110793 A1, ;
Page/Page column 111 ;
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=25°C; 16 h;
参考文献
Hsu, He-Chu; Hou, Duen-Ren
Tetrahedron Letters, 2009 , vol. 50, # 51 p. 7169 - 7171
反应条件
1: TEA; DMAP / CH2Cl2 2: NaBH4 / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 23 p. 5059 - 5068
反应条件
1: TEA; DMAP / CH2Cl2 2: NaBH4 / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 23 p. 5059 - 5068
反应条件
1: 1 N KOH / tetrahydrofuran; H2O / 6 h / Ambient temperature 2: 100 percent / NaBH4 / ethanol / 6 h / 20 °C View Scheme
参考文献
Liebigs Annalen der Chemie, , # 2 p. 413 - 417
反应条件
4 A molecular sieve; polymer intercalated (RuCl2(PPh3)3) in acetone T=30°C; 2 h;
参考文献
Kobayashi, Shu; Miyamura, Hiroyuki; Akiyama, Ryo; Ishida, Tasuku
Journal of the American Chemical Society, 2005 , vol. 127, # 25 p. 9251 - 9254
反应条件
in tetrachloromethane; hexane
参考文献
Indiana University Foundation
Patent: US5554753 A1, 1996 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran; N,N-dimethyl-formamide / 16 h 2: sodium hydroxide / water; dimethyl sulfoxide 3: trifluoroacetic acid / chloroform / 0.17 h View Scheme
参考文献
Russian Chemical Bulletin, , vol. 59, # 2 p. 457 - 462
