1,3-二苯基-1H-吡唑-5-羧酸合成路线 （共 16 条）
反应条件
1: With sodium hydrogencarbonate in methanol
T=0 - 60°C; 2 h;
2: With sodium hydroxide in methanol; water
T=80°C; 2 h;
3: With hydrogenchloride in methanol; water
pH=3;
参考文献
Sun, Yufeng; Qiao, Huili; Ling, Yun; Yang, Shaoxiang; Rui, Changhui; Pelosi, Paolo; Yang, Xinling
Journal of Agricultural and Food Chemistry, 2011 , vol. 59, # 6 p. 2456 - 2461
反应条件
triethylamine; sodium iodide in acetonitrile
T=20°C;
参考文献
Clovis, James S.; Fliege, Werner; Huisgen, Rolf
Chemische Berichte, 1983 , vol. 116, # 9 p. 3062 - 3070
反应条件
sulfuric acid; acetic acid
10 h; Heating;
参考文献
Khlopushina, T. G.; Krinskaya, A. V.; Kirsanova, Z. D.; Zykov, D. A.; Zagorevskii, V. A.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 11 p. 760 - 763
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 11 p. 10 - 13
反应条件
1: 1.) Et3N, 2.) MnO2 / 1.) benzene, 72 h, reflux; 2.) CCl4, 1 h
2: K2CO3, KMnO4 / H2O / 8 h / Heating
View Scheme
参考文献
Ballabio, Marzia; Croce, Piero Dalla; Massari, Valeria; Pocar, Donato; Riva, Alberto; Trimarco, Pasqualina
Journal of Chemical Research, Miniprint, 1983 , # 6 p. 1317 - 1340
反应条件
1: concd. H2SO4 / ethanol; H2O / 1 h / Heating
2: 33percent NaOH
View Scheme
参考文献
Begtrup, Mikael; Vedso, Per; Cabildo, Pilar; Claramunt, Rosa Maria; Elguero, Jose; Meutermans, Wim
Magnetic Resonance in Chemistry, 1992 , vol. 30, # 5 p. 455 - 459
反应条件
1: concd. H2SO4 / ethanol; H2O / 1 h / Heating
2: 33percent NaOH
View Scheme
参考文献
Begtrup, Mikael; Vedso, Per; Cabildo, Pilar; Claramunt, Rosa Maria; Elguero, Jose; Meutermans, Wim
Magnetic Resonance in Chemistry, 1992 , vol. 30, # 5 p. 455 - 459
反应条件
potassium permanganate; potassium carbonate in water
8 h; Heating;
参考文献
Ballabio, Marzia; Croce, Piero Dalla; Massari, Valeria; Pocar, Donato; Riva, Alberto; Trimarco, Pasqualina
Journal of Chemical Research, Miniprint, 1983 , # 6 p. 1317 - 1340
反应条件
1: 51.8 percent / KMnO4 / acetone / 1 h / 20 °C
2: 81.2 percent / aq. acetic acid, sulfuric acid / 10 h / Heating
View Scheme
参考文献
Khlopushina, T. G.; Krinskaya, A. V.; Kirsanova, Z. D.; Zykov, D. A.; Zagorevskii, V. A.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 11 p. 760 - 763
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 11 p. 10 - 13
反应条件
1.1: ethanol; sodium / 4 h / 10 °C
2.1: sodium hydrogencarbonate / methanol / 2 h / 0 - 60 °C
2.2: 2 h / 80 °C
2.3: pH 3
View Scheme
参考文献
Sun, Yufeng; Qiao, Huili; Ling, Yun; Yang, Shaoxiang; Rui, Changhui; Pelosi, Paolo; Yang, Xinling
Journal of Agricultural and Food Chemistry, 2011 , vol. 59, # 6 p. 2456 - 2461
反应条件
potassium permanganate in pyridine
Heating;
参考文献
Fliege, Werner; Huisgen, Rolf; Kolbeck, Winfried; Weberndoerfer, Volkmar
Chemische Berichte, 1983 , vol. 116, # 10 p. 3438 - 3460
