3-苯基-L-丙氨酸苄酯合成路线 （共 14 条）
反应条件
1.1: CH2Cl2 / 5 h / Heating 2.1: lithium diisopropylamide; TiCl4*2THF; (2R,3R)-1,4-dimethoxy-1,1,4,4,-tetraphenylbutane-2,3-diol / tetrahydrofuran / 0.5 h / -60 °C 2.2: tetrahydrofuran / 12 h / -15 °C 2.3: hydrochloric acid / tetrahydrofuran; H2O / 10 h / Heating View Scheme
参考文献
Hu, Ai-Guo; Zhang, Ling-Yun; Wang, Shan-Wei; Wang, Ji-Tao
Synthetic Communications, 2002 , vol. 32, # 14 p. 2143 - 2147
参考文献
Biondini, Daniele; Brinchi, Lucia; Germani, Raimondo; Goracci, Laura; Savelli, Gianfranco
Letters in Organic Chemistry, 2010 , vol. 7, # 1 p. 39 - 44
反应条件
Alcalase; 3,5-dichloro-benzaldehyde in water; acetonitrile T=35°C; pH=8.5; 24 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Schichl, Daniel A.; Enthaler, Stephan; Holla, Wolfgang; Riermeier, Thomas; Kragl, Udo; Beller, Matthias
European Journal of Organic Chemistry, 2008 , # 20 p. 3506 - 3512
反应条件
1.1: CH2Cl2 / 5 h / Heating 2.1: lithium diisopropylamide; TiCl4*2THF; (2R,3R)-1,4-dimethoxy-1,1,4,4,-tetraphenylbutane-2,3-diol / tetrahydrofuran / 0.5 h / -60 °C 2.2: tetrahydrofuran / 12 h / -15 °C 2.3: hydrochloric acid / tetrahydrofuran; H2O / 10 h / Heating View Scheme
参考文献
Hu, Ai-Guo; Zhang, Ling-Yun; Wang, Shan-Wei; Wang, Ji-Tao
Synthetic Communications, 2002 , vol. 32, # 14 p. 2143 - 2147
反应条件
triethylamine in acetonitrile 1 h; Ambient temperature; Yield given;
参考文献
Furukawa, M.; Hokama, N.; Okawara, T.
Synthesis, 1983 , # 1 p. 42 - 44
反应条件
tetrachloromethane; triethylamine; triphenylphosphine in acetonitrile
参考文献
Appel,R. et al.
Chemische Berichte, 1975 , vol. 108, p. 2680 - 2692
参考文献
N. V. Organon
Patent: DE1013656 , 1957 ;
Full Text Show Details
N. V. Organon
Patent: US2793204 , 1956 ;
反应条件
4-methyl-morpholine in dichloromethane T=-15°C; 1 h;
参考文献
Zou, Weibiao; Ibrahem, Ismail; Dziedzic, Pawel; Sunden, Henrik; Cordova, Armando
Chemical Communications, 2005 , # 39 p. 4946 - 4948
反应条件
triethylamine in acetonitrile 1 h; Ambient temperature; Yield given;
参考文献
Furukawa, M.; Hokama, N.; Okawara, T.
Synthesis, 1983 , # 1 p. 42 - 44
反应条件
1: ethyl acetate 2: H2, AcOH / Pd View Scheme
参考文献
Mazur,R.H. et al.
Journal of the American Chemical Society, 1969 , vol. 91, p. 2684 - 2691
