3'-O-苄基-2'-脱氧-5-三氟甲基尿苷合成路线 （共 23 条）
反应条件
1: 72 percent / 0.1 N NaOEt / 2 h / Ambient temperature
2: 1.) pyridine, DMF, copper powder, 4-dimethylaminopyridine / 1.) < -70 to 115 deg C; sealed tube, 2.) 8 h, 60 deg C; sealed tube was opened
View Scheme
参考文献
Yamashita; Matsumotot; Kobayashi; Noguchi; Yasumoto; Ueda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2287 - 2292
反应条件
1: 1.) pyridine, copper powder, 4-dimethylaminopyridine, DMF / 1.) RT, -115 deg C; sealed tube, 2.) toluene, 8 h, 60 deg C; sealed tube was opened
2: methanolic HCl (2 percent) / 2 h / Ambient temperature
View Scheme
参考文献
Yamashita; Matsumotot; Kobayashi; Noguchi; Yasumoto; Ueda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2287 - 2292
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine; copper; N,N-dimethyl-formamide
1.) < -70 to 115 deg C; sealed tube, 2.) 8 h, 60 deg C; sealed tube was opened; Yield given. Multistep reaction;
参考文献
Yamashita; Matsumotot; Kobayashi; Noguchi; Yasumoto; Ueda
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2287 - 2292
