1: 4 h / Heating 2: 1N HCl / trifluoroacetic acid / 0.33 h / 60 - 65 °C 3: sodium dithionite / dimethylformamide; H2O / 2 h / 60 - 65 °C 4: 0.1 N NaOH, / acetonitrile / 18 h / 25 °C 5: MeOH, 5percent KMnO4 / acetonitrile / 0.5 h / 25 °C View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: zinc / acetic acid / 4 h / 25 &deg;C<br />2: 92 percent / pyridine, hydroxylamine hydrochloride / methanol / 1 h / Heating<br />3: 74 percent / 95percent hydrazine hydrate / methanol / 72 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 98 percent / tetrahydrofuran / 4 h / Heating<br />2: 77 percent / 1N NaOH / dimethylformamide; methanol / 18 h / 60 &deg;C<br />3: zinc / acetic acid / 4 h / 25 &deg;C<br />4: 92 percent / pyridine, hydroxylamine hydrochloride / methanol / 1 h / Heating<br />5: 74 percent / 95percent hydrazine hydrate / methanol / 72 h / Heating<br /> <br /> &nbsp;