1: With N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one; water T=-20 - -5°C; 2: With 4-methyl-morpholine; hydrogenchloride; 5 Pd(II)/C(eggshell); hydrogen in 1-methyl-pyrrolidin-2-one; water T=25°C; pH=6.5 - 7;
参考文献
DAEWOONG BIO INC.; DAEWOONG PHARMACEUTICAL CO., LTD.
Patent: US2012/65392 A1, 2012 ;
Location in patent: Page/Page column 6 ;