sodium methylate in methanol T=5°C; pH = 10.5;

<b>Multi-step reaction with 4 steps<br /> </b>1: 72 percent / AgClO₄, molecular sieve / toluene; CH₂Cl₂ / -50 &deg;C<br />2: 1.) H₂S, (C₂H₅)3N / 1.) pyridine, water, 25 h, room temperature, 2.) 22 h, room temperature<br />3: 98 percent / 98 percent HCOOH / 16 h / Ambient temperature<br />4: 97 percent Pd / 2 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 97 percent / TiBr₄ / CH₂Cl₂; ethyl acetate / 6 h / 20 &deg;C<br />2: 85 percent / molecular sieves 4 Angstroem / Ag₂CO₃/AgClO₄ / toluene; CH₂Cl₂ / 8 h / 20 &deg;C<br />3: 1.) NiCl₂, NaBH₄; 2.) pyridine / 1.) ethanol, 1 h; 2.) 6 h, 20 deg C<br />4: 87 percent / H₂ / Pd/C / methanol / 6 h / 20 &deg;C<br /> <br /> &nbsp;