4-氯-3-硝基苯甲酸合成路线 （共 122 条）
反应条件
1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 18 h / 100 °C / |Inert atmosphere 2: palladium 10 on activated carbon; ammonium formate / methanol / 2 h / |Inert atmosphere; |Reflux View Scheme
参考文献
GALAPAGOS NV; MENET, Christel Jeanne Marie; SCHMITT, Benoît Antoine; GENEY, Raphaël Jean Joël; DOYLE, Kevin James; PEACH, Joanne; PALMER, Nicholas John; JONES, Graham Peter; HARDY, David; DUFFY, James Edward Stewart
Patent: WO2013/117645 A1, 2013 ;
反应条件
oxygen T=500 - 900°C; Oxidation; pyrolysis; Formation of xenobioticscombustion;
参考文献
Vikelsoe; Johansen
Chemosphere, 2000 , vol. 40, # 2 p. 165 - 175
反应条件
oxygen T=500 - 900°C; Oxidation; pyrolysis; Formation of xenobioticscombustion; Product distribution; Further Variations:TemperaturesReagentsair inflow;
参考文献
Vikelsoe; Johansen
Chemosphere, 2000 , vol. 40, # 2 p. 165 - 175
反应条件
1: oxalyl dichloride / N,N-dimethyl-formamide / monofluorodichloromethane / 2 h / 20 °C 2: ammonia / dichloromethane; chloroform; methanol / cooling with ice 3: bis-trimethylsilyl ether; phosphorous pentoxide / chloroform / 2 h / Inert atmosphere; Reflux View Scheme
参考文献
GLAXOSMITHKLINE LLC; HALLMAN, Jason; LAUDEMAN, Christopher; LIU, Ronggang; MILLER, Aaron; MOORE, Michael, Lee; DOCK, Steven; MUSSO, David; PARRISH, Cynthia
Patent: WO2011/56635 A1, 2011 ;
WO 2011/056635 A1
反应条件
1: Cu, N-methylmorpholine / 3-methyl-butan-1-ol / 18 h / Heating 2: HCl(g) / 18 h / Heating 3: H2 / 5 percent Pd/C / methanol; ethyl acetate 4: 2-methoxy-ethanol / 3 h / Heating View Scheme
参考文献
Palmer, Brian D.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 27 p. 5457 - 5465
反应条件
1: 85 percent / pyridine / 8 h / Heating 2: 100 percent / H2SO4 / 5 h / Heating 3: 33 percent / H2 / 10 percent Pd/C / ethanol / 2 h / 50 °C View Scheme
参考文献
Yamamoto, Takeshi; Hori, Manabu; Watanabe, Ikuo; Harada, Kengo; Ikeda, Shoji; Ohtaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 6 p. 843 - 849
反应条件
1: thionyl chloride / tetrahydrofuran 2: pyridine / tetrahydrofuran View Scheme
参考文献
Colthurst, Matthew J.; Williams, Andrew
Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 8 p. 1493 - 1497
反应条件
1.1: Na2S / 0.33 h / Heating 1.2: 77.6 percent / acetic acid / 0.33 h / Heating 2.1: lithium aluminum hydride / tetrahydrofuran / 2 h / Heating 3.1: 94.7 percent / SO3*pyridine; DMSO; triethylamine / CH2Cl2 / 2 h / 23 °C View Scheme
参考文献
Xu, Ju-Hua; Li, Yu-Liang; Zhu, Dao-Ben
Synthetic Communications, 2002 , vol. 32, # 11 p. 1647 - 1652
反应条件
1: PCl5 2: diethyl ether View Scheme
参考文献
Shiseido Co., Ltd.
Patent: US6204264 B1, 2001 ;
反应条件
1: 70 percent / H2O / 160 °C 2: 100 percent / SOCl / Heating View Scheme
参考文献
Dumont-Hornebeck, Beatrice; Strube, Yi Ning; Vasilescu, Daniela; Jean-Claude, Bertrand Jacques
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 20 p. 2325 - 2327
