4-甲基-3-硝基苯甲酸合成路线 （共 85 条）
反应条件
1: 87 percent / POCl2 / pyridine / 3 h / 60 - 70 °C
2: 63 percent / NaH / tetrahydrofuran / 2.5 h / Heating
3: 54 percent / iodine / 3 h / 80 - 90 °C
View Scheme
参考文献
Barros, Ana I. R. N. A.; Silva, Artur M. S.
Monatshefte fur Chemie, 2006 , vol. 137, # 12 p. 1505 - 1528
反应条件
1: thionyl chloride / 3 h / Heating
2: 95 percent / 8 h / Heating
3: 60 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 15 h / Heating
View Scheme
参考文献
Desrousseaux; Bennetau; Morand; Mingotaud; Letard; Montant; Freysz
New Journal of Chemistry, 2000 , vol. 24, # 12 p. 977 - 985
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
2: triethylamine / dichloromethane / 20 °C
3: palladium 10 on activated carbon; hydrogen / ethanol / 20 °C
View Scheme
参考文献
Brown, Dearg S.; Cumming, John G.; Bethel, Paul; Finlayson, Jonathan; Gerhardt, Stefan; Nash, Ian; Pauptit, Richard A.; Pike, Kurt G.; Reid, Alan; Snelson, Wendy; Swallow, Steve; Thompson, Caroline
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3879 - 3883
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
2: triethylamine / dichloromethane / 20 °C
3: palladium 10 on activated carbon; hydrogen / ethanol / 20 °C
View Scheme
参考文献
Brown, Dearg S.; Cumming, John G.; Bethel, Paul; Finlayson, Jonathan; Gerhardt, Stefan; Nash, Ian; Pauptit, Richard A.; Pike, Kurt G.; Reid, Alan; Snelson, Wendy; Swallow, Steve; Thompson, Caroline
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3879 - 3883
反应条件
1: permanganate; NaOH-solution
2: phosphorus pentachloride / 100 °C
View Scheme
参考文献
Soderman; Johnson
Journal of the American Chemical Society, 1925 , vol. 47, p. 1394
