7-氟-1,5-萘啶-2(1h)-酮合成路线 （共 5 条）
反应条件
1: With hydrogen bromide; acetic acid
T=20°C; 18 h;
2: With water; sodium hydrogencarbonate
T=20°C; pH=4; 1 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/9700 A1, 2008 ;
Location in patent: Page/Page column 41 ;
WO 2008/009700 A1
反应条件
triethylamine; Pd0(tris(tert-butyl)phosphine)2
T=145 - 150°C; 5 h;
参考文献
TOYAMA CHEMICAL CO., LTD.; Taisho Pharmaceutical Co. Ltd.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 32 ;
Title/Abstract Full Text Show Details
Taisho Pharmaceutical Co. Ltd.; TOYAMA CHEMICAL CO., LTD.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 32 ;
EP 2022793 A1
反应条件
sodium methylate in methanol
T=20°C; 5.33333 h; Heating / reflux; Product distribution / selectivity;
参考文献
TOYAMA CHEMICAL CO., LTD.; Taisho Pharmaceutical Co. Ltd.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 32-33 ;
Title/Abstract Full Text Show Details
Taisho Pharmaceutical Co. Ltd.; TOYAMA CHEMICAL CO., LTD.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 32-33 ;
EP 2022793 A1
反应条件
water; potassium carbonate; p-toluenesulfonyl chloride in chloroform
T=20°C; Product distribution / selectivity;
参考文献
TOYAMA CHEMICAL CO., LTD.; Taisho Pharmaceutical Co. Ltd.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 108 ;
Title/Abstract Full Text Show Details
Taisho Pharmaceutical Co. Ltd.; TOYAMA CHEMICAL CO., LTD.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 108 ;
EP 2022793 A1
反应条件
sodium hydroxide in tert-butyl methyl ether; water
参考文献
Voight, Eric A.; Yin, Hao; Downing, Susan V.; Calad, Stacie A.; Matsuhashi, Hayao; Giordano, Ilaria; Hennessy, Alan J.; Goodman, Richard M.; Wood, Jeffery L.
Organic Letters, 2010 , vol. 12, # 15 p. 3422 - 3425
