N-(2-乙氧基乙基)-1,2-苯二胺合成路线 （共 8 条）
反应条件
1: 69 percent / 5 h / 150 °C 2: 82 percent / POCl3 / 0.5 h / Heating 3: 81 percent / 4 h / 120 °C View Scheme
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
5 palladium on charcoal; hydrogen in ethanol
T=5 - 10°C; P=2250.23 - 3000.3 Torr; 3 h;
参考文献
ZENTIVA, K.S; ZEZULA, Josef; HAJICEK, Josef
Patent: WO2014/26657 A2, 2014 ;
Location in patent: Page/Page column 14 ;
反应条件
1: 78 percent / 3 h / Heating
2: 77 percent / 10percent aq. NaOH, Zn / ethanol / Heating
View Scheme
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
1: 55.5 percent / NaH in oil / dimethylformamide / 30 - 35 °C
2: Zn; HCl
View Scheme
参考文献
Goeker, Hakan; Ayhan-Kilcigil, Guelguen; Tuncbilek, Meral; Kus, Canan; Ertan, Rahmiye; Kendi, Engin; Oezbey, Sueheyla; Fort, Merce; Garcia, Celia; Farre, Antonio J.
Heterocycles, 1999 , vol. 51, # 11 p. 2561 - 2573
反应条件
hydrogenchloride
15 h; Heating;
参考文献
Iemura; Kawashima; Fukuda; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 31 - 37
反应条件
1: Heating
2: POCl3
View Scheme
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
1: 69 percent / 5 h / 150 °C
2: 82 percent / POCl3 / 0.5 h / Heating
3: 96 percent / 4 h / 120 °C
View Scheme
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
