1.1: I2; Mg / tetrahydrofuran / 1 h / Heating 1.2: 90 percent / tetrahydrofuran / 0 - 20 °C 2.1: 92 percent / LiALH4 / tetrahydrofuran / 4 h / Heating 3.1: 83 percent / PBr3; pyridine / diethyl ether / -78 - 20 °C View Scheme

1: 1-((4-bromo-3,5-dimethylphenoxy)methyl)benzene With iodine; magnesium in tetrahydrofuran Grignard reaction; 1 h; Heating; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0 - 20°C; Formylation;

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1: With potassium carbonate in acetonitrile T=20°C; 16 h; 2: With hydrogenchloride in water; acetonitrile

1: 4-Br-3,5-dimethylphenol With sodium hydroxide in methanol T=0°C; Metallation; 2 h; 2: benzyl chloride in ethylene glycol dimethyl ether T=35°C; Etherification; 24 h;

1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=20°C; 3: With hydrogenchloride in tetrahydrofuran; hexane; water 2.5 h;