Cbz-反式-4-羟基-L-脯氨醇合成路线 （共 6 条）
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=0°C; 13 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1623975 A1, 2006 ;
Location in patent: Page/Page column 20-21 ;
反应条件
lithium borohydride in tetrahydrofuran T=0 - 20°C;
参考文献
Spirogen Limited
Patent: EP1193270 A2, 2002 ;
Location in patent: Page 14, 36, 105 ;
反应条件
borane in tetrahydrofuran; water
参考文献
Braish; Tamim F.; Fox; Darrell E.
Patent: US5036153 A1, 1991 ;
反应条件
in tetrahydrofuran; methanol; dichloromethane
参考文献
MicroProbe Corporation
Patent: US5419966 A1, 1995 ;
反应条件
1: 98 percent / Et3N; aq. NaHCO3 / toluene / 8 h / 20 °C 2: 91 percent / SOCl2; Et3N / 7 h / 20 °C 3: 88 percent / LiCl; NaBH4 / tetrahydrofuran; ethanol / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 10 p. 2321 - 2330
反应条件
1: 98 percent / Et3N; aq. NaHCO3 / toluene / 8 h / 20 °C 2: 91 percent / SOCl2; Et3N / 7 h / 20 °C 3: 88 percent / LiCl; NaBH4 / tetrahydrofuran; ethanol / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 10 p. 2321 - 2330
