N-Cbz-3-羟基吡咯烷合成路线 （共 26 条）
反应条件
Pseudomonas cepacia AK lipase in dichloromethane T=20°C; 240 h;
参考文献
Barreto, Ricardo de L.; Carpes, Marcos J.S.; Santana, Cesar C.; Correia, Carlos R.D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 3 p. 435 - 442
反应条件
PS-IM lipase in toluene T=20°C; 3 h; Inert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Lihammar, Richard; Millet, Renaud; Baeckvall, Jan-E.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 13 p. 2321 - 2327
反应条件
PS-IM lipase in toluene T=20°C; 3 h; Inert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Lihammar, Richard; Millet, Renaud; Baeckvall, Jan-E.
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 13 p. 2321 - 2327
反应条件
1: pyridine, DMPA / CH2Cl2 / 4 h / Ambient temperature 2: 44 percent / phosphate buffer (pH 7.0) / dioxane / 24 h / 25 °C / lipase PS View Scheme
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
参考文献
Luna, Amparo; Gutierrez, Maria-Concepcion; Furstoss, Roland; Alphand, Veronique
Tetrahedron Asymmetry, 2005 , vol. 16, # 15 p. 2521 - 2524
反应条件
1: triethylamine / dichloromethane / 0 °C
2: potassium carbonate / N,N-dimethyl-formamide / 10 - 80 °C
View Scheme
参考文献
Zhersh, Sergey; Buryanov, Volodymyr V.; Karpenko, Oleksandr V.; Grygorenko, Oleksandr O.; Tolmachev, Andrey A.
Synthesis, 2011 , # 22 art. no. Z72611SS, p. 3669 - 3674
