N-Cbz-3-羟基吡咯烷合成路线 （共 26 条）
反应条件
potassium carbonate in tetrahydrofuran T=20°C; 16 h;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 77 ;
反应条件
1: With borane in tetrahydrofuran T=0 - 20°C; 16 h; 2: With sodium hydroxide; water; dihydrogen peroxide in tetrahydrofuran T=0 - 20°C; 2.5 h; 3: With water; sodium hydrogensulfite in tetrahydrofuran 0.25 h;
参考文献
Actelion Pharmaceuticals Ltd.
Patent: US2009/247578 A1, 2009 ;
Location in patent: Page/Page column 14 ;
反应条件
sodium hydroxide in tetrahydrofuran; water T=20°C; 3 h;
参考文献
US2007/161685 A1, ;
Page/Page column 126 ;
反应条件
sodium carbonate in diethyl ether; water
参考文献
Chemical Communications, , # 21 p. 2136 - 2138
反应条件
sodium hydroxide; sodium chloride in water
反应条件
sodium hydroxide in diethyl ether 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 8 p. 1393 - 1398
反应条件
sodium chloride; triethylamine in dichloromethane; toluene
反应条件
triethylamine in dichloromethane T=-60 - 20°C; 0.75 h; under argon;
参考文献
Nortran Pharmaceuticals Inc.
Patent: EP1087934 B1, 2004 ;
Location in patent: Page 25-26 ;
反应条件
1: iPr2NEt / tetrahydrofuran / 0 °C 2: aq. HCl View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 15 p. 2521 - 2524
