2-氨基-N-(2-氯吡啶-3-基)苯甲酰胺合成路线 （共 16 条）
反应条件
T=205°C; 0.0833333 h;
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 17 p. 4300 - 4315
反应条件
PPA; water; ammonium chloride 1) 160 deg C, 4 h, 2) r.t.; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 20, p. 1339 - 1349
反应条件
1: 80 percent / 0.08 h / 205 °C 2: 70 percent / Et3N / dioxane / 8 h / Heating View Scheme
参考文献
Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844
反应条件
1: 1) NH4Cl, polyphosphoric acid, 2) H2O / 1) 160 deg C, 4 h, 2) r.t. 2: 95 percent / 40percent H2O2, acetic acid / 50 deg C, 3 h, then 20-25 deg C, 24 h 3: acetonitrile / 2 h / 80 °C 4: 95 percent / toluene / 2 h / 80 °C 5: 100 percent / H2 / Raney nickel / bis-(2-methoxy-ethyl) ether / 16 h / 50 °C View Scheme
参考文献
Hulinska, Hana; Polivka, Zdenek; Jilek, Jiri; Sindelar, Karel; Holubek, Jiri; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 8 p. 1820 - 1844
反应条件
hydrogenchloride; tin(ll) chloride
T=100°C; 0.25 h;
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
ammonium hydroxide; copper(l) chloride; sodium chloride
T=80°C; 3 h;
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: oxalyl chloride; DMF / tetrahydrofuran / 1 h / Heating
2: 5.55 g / pyridine / tetrahydrofuran / 2 h / 20 °C
3: 86 percent / aq. HCl; SnCl2 / 0.25 h / 100 °C
View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
1: 5.55 g / pyridine / tetrahydrofuran / 2 h / 20 °C
2: 86 percent / aq. HCl; SnCl2 / 0.25 h / 100 °C
View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
triethylamine in 1,4-dioxane
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 94 percent / triethylamine / dioxane
2: 0.12 g / 0.08 h / 200 °C
3: N-bromosuccinimide, azobisisobutyronitrile / CCl4 / 1 h / Heating
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
