1: 4-(trifluoromethyl)pyridine-3-carboxylic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine in tetrahydrofuran T=20°C; 0.166667 h; 2: 2,2-Dimethyl-[1,3]dioxane-4,6-dione in tetrahydrofuran T=20°C; 18 h; 3: With hydrogenchloride; sodium hydrogencarbonate more than 3 stages;

PyBOP; triethylamine in tetrahydrofuran T=20°C; 18 h;