2-氨甲基-3-苯基丙酸合成路线 （共 24 条）
反应条件
hydrogenchloride; acetic acid in water T=120°C; 48 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/121786 A1, 2008 ;
Location in patent: Page/Page column 44 ;
WO 2008/121786 A1
反应条件
hydrogenchloride; water in methanol T=20°C; 0.5 h;
参考文献
Lin, Daizong; Lv, Li; Wang, Jiang; Ding, Xiao; Jiang, Hualiang; Liu, Hong
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6649 - 6656
反应条件
hydrogenchloride T=180°C; 8 h;
参考文献
Juaristi, Eusebio; Quintana, Delia; Lamatsch, Bernd; Seebach, Dieter
Journal of Organic Chemistry, 1991 , vol. 56, # 7 p. 2553 - 2557
反应条件
hydroxylamine hydrochloride; sodium ethanolate in ethanol Heating;
参考文献
Xie; Soleilhac; Schmidt; Peyroux; Roques; Fournie-Zaluski
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1497 - 1503
反应条件
hydrogenchloride Heating;
参考文献
Jackson, W. Roy; Perlmutter, Patrick; Smallridge, Andrew J.
Australian Journal of Chemistry, 1988 , vol. 41, # 8 p. 1201 - 1208
反应条件
1: Ni<P(OPh)3> / 18 h / 120 °C 2: 98 percent / H2 / 10percent Pd/CaCO3 / ethyl acetate / 6 h / 70 °C / 7757.2 Torr 3: 90 percent / 30percent aq. HCl / 14 h / Heating View Scheme
参考文献
Australian Journal of Chemistry, , vol. 41, # 8 p. 1201 - 1208
反应条件
1: 88 percent / tributylcetylphosphonium bromide / toluene / 4 h / 60 °C 2: Ni<P(OPh)3> / 18 h / 120 °C 3: 98 percent / H2 / 10percent Pd/CaCO3 / ethyl acetate / 6 h / 70 °C / 7757.2 Torr 4: 90 percent / 30percent aq. HCl / 14 h / Heating View Scheme
参考文献
Australian Journal of Chemistry, , vol. 41, # 8 p. 1201 - 1208
反应条件
1: 50 percent / K2CO3 / tetrabutylammonium bromide / 5 h / 20 °C 2: Raney-Ni of W-2, NaOAc, hydrogen / acetic anhydride / 12 h / 50 °C / 15514.4 Torr 3: conc. HCl / acetic acid; H2O / 12 h / Heating View Scheme
参考文献
Phytochemistry (Elsevier), , vol. 27, # 3 p. 711 - 714
反应条件
1: 98 percent / H2 / 10percent Pd/CaCO3 / ethyl acetate / 6 h / 70 °C / 7757.2 Torr 2: 90 percent / 30percent aq. HCl / 14 h / Heating View Scheme
参考文献
Australian Journal of Chemistry, , vol. 41, # 8 p. 1201 - 1208
反应条件
1: 98 percent / Et3N / CH2Cl2 / 2 h / 0 °C 2: 88 percent / tributylcetylphosphonium bromide / toluene / 4 h / 60 °C 3: Ni<P(OPh)3> / 18 h / 120 °C 4: 98 percent / H2 / 10percent Pd/CaCO3 / ethyl acetate / 6 h / 70 °C / 7757.2 Torr 5: 90 percent / 30percent aq. HCl / 14 h / Heating View Scheme
参考文献
Australian Journal of Chemistry, , vol. 41, # 8 p. 1201 - 1208
