1.1: R-(+)-proline / water; dimethyl sulfoxide / 0.5 h / 30 °C 2.1: methanol; sodium tetrahydroborate / water; dimethyl sulfoxide / 0.5 h / 0 °C 3.1: palladium 10 on activated carbon; chloroform; hydrogen / ethanol / 12 h 4.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere 4.2: 15 h / 20 °C / Inert atmosphere 5.1: N,N-dimethyl-formamide / 19 h / 75 °C / Inert atmosphere 6.1: dihydrogen peroxide; sodium hydroxide / water / 3 h / 100 °C 6.2: pH Ca. 1 View Scheme