3-(4-氟苯基)-5-甲基异恶唑-4-羧酸乙酯合成路线 （共 7 条）
反应条件
1: 4-fluorobezaldoxime With N-chloro-succinimide in N,N-dimethyl-formamide T=20°C; 1.5 h; 2: ethyl 3-(pyrrolidin-1-yl)but-2-enoate in N,N-dimethyl-formamide T=20°C; 28 h;
参考文献
Hoffmann-La Roche Inc.; Dott, Pascal; Grassmann, Olaf; Kammerer, Michael; Manns, Joachim; Schwitter, Urs; Thomas, Andrew; Wyttenbach, Nicole
Patent: US2013/172329 A1, 2013 ;
Location in patent: Paragraph 0257 ;
反应条件
triethylamine in diethyl ether T=0 - 20°C;
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; GRASSMANN, Olaf; KAMMERER, Michael; MANNS, Joachim; SCHWITTER, Urs; THOMAS, Andrew; WYTTENBACH, Nicole
Patent: WO2013/57124 A1, 2013 ;
Location in patent: Page/Page column 33 ;
反应条件
in N,N-dimethyl-formamide T=20°C; 28 h;
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; GRASSMANN, Olaf; KAMMERER, Michael; MANNS, Joachim; SCHWITTER, Urs; THOMAS, Andrew; WYTTENBACH, Nicole
Patent: WO2013/57124 A1, 2013 ;
Location in patent: Page/Page column 36 ;
参考文献
Buettelmann, Bernd; Jakob-Roetne, Roland; Knust, Henner; Thomas, Andrew
Patent: US2009/143385 A1, 2009 ;
反应条件
1.1: hydroxylamine hydrochloride / water / 0 - 25 °C 2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C 2.2: 28 h / 20 °C View Scheme
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 20 - 35 °C 2: N,N-dimethyl-formamide / 28 h / 20 °C View Scheme
反应条件
sodium hydroxide in ethanol T=20 - 30°C; 5 h;
参考文献
Hoffmann-La Roche Inc.; Dott, Pascal; Grassmann, Olaf; Kammerer, Michael; Manns, Joachim; Schwitter, Urs; Thomas, Andrew; Wyttenbach, Nicole
Patent: US2013/172329 A1, 2013 ;
Location in patent: Paragraph 0258 ;
