5-溴-4-氟-2-甲氧基苯甲酸合成路线 （共 2 条）
反应条件
bromine; acetic acid
T=10 - 35°C; 2 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/15588 A1, 2007 ;
Location in patent: Page/Page column 90-91 ;
WO 2007/015588 A1
反应条件
1: With triethylamine; isobutyl chloroformate in tetrahydrofuran
T=10 - 35°C; 0.5 h;
2: With sodium tetrahydroborate in water
T=10 - 35°C; 1 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/15588 A1, 2007 ;
Location in patent: Page/Page column 91 ;
WO 2007/015588 A1
