(R)-3-甲基吗啉盐酸盐合成路线 （共 3 条）
反应条件
hydrogenchloride; hydrogen; palladium 10 on activated carbon in methanol; water T=20°C;
参考文献
WO2010/59658 A1, ;
Page/Page column 182-183 ;
WO 2010/059658 A1
反应条件
1: With 1-chloroethyl chlorocarbonate in 1,2-dichloro-ethane T=80°C; 6 h; 2: With methanol T=80°C; 1 h;
参考文献
MITSUBISHI PHARMA CORPORATION; SANOFI-AVENTIS
Patent: WO2007/119463 A1, 2007 ;
Location in patent: Page/Page column 197; 198 ;
WO 2007/119463 A1
反应条件
1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0 - 60 °C 2: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1871 - 1895
