3-(3,5-二氯苯基)-丙醛合成路线 （共 5 条）
反应条件
tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate in N,N-dimethyl-formamide
T=50°C;
参考文献
Uto, Yoshikazu; Ogata, Tsuneaki; Harada, Jun; Kiyotsuka, Yohei; Ueno, Yuko; Miyazawa, Yuriko; Kurata, Hitoshi; Deguchi, Tsuneo; Watanabe, Nobuaki; Takagi, Toshiyuki; Wakimoto, Satoko; Okuyama, Ryo; Abe, Manabu; Kurikawa, Nobuya; Kawamura, Sayako; Yamato, Michiko; Osumi, Jun
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4151 - 4158
反应条件
1: 69 percent / piperidine / 1.) 100 deg C, 2 h, 2.) 155 deg C, 1 h
2: 95 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr
3: 98 percent / 1 M BH3*THF / tetrahydrofuran / 2 h / Ambient temperature
4: 1.) oxalyl chloride, Me2SO, 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) CH2Cl2, -60 deg C, 5 min
View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1: 95 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 5 h / 2585.7 Torr
2: 98 percent / 1 M BH3*THF / tetrahydrofuran / 2 h / Ambient temperature
3: 1.) oxalyl chloride, Me2SO, 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) CH2Cl2, -60 deg C, 5 min
View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1: 98 percent / 1 M BH3*THF / tetrahydrofuran / 2 h / Ambient temperature
2: 1.) oxalyl chloride, Me2SO, 2.) NEt3 / 1.) CH2Cl2, -60 deg C, 10 min, 2.) CH2Cl2, -60 deg C, 5 min
View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine
1.) CH2Cl2, -60 deg C, 10 min, 2.) CH2Cl2, -60 deg C, 5 min; Yield given. Multistep reaction;
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
